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Health Technology Assessment

Health Technology Assessment (HTA) is a multi-disciplinary process for supporting evidence-based decision making about health technologies by considering medical, economic, social, ethical and other relevant aspects. Health technology refers to equipment, drugs or procedures used by health care professionals. Between 2004-2019 I was a part of the Technology Assessment Unit of the McGill University Health Centre. As a Biostatistician, I have also contributed to the meta-analysis portion of many systematic reviews, including some published by the Cochrane Collaboration.

Please click on the buttons below to see some of my interests in this area:

MUHC TAU
Cochrane Handbook for Diagnostic Test Accuracy Reviews
HTA Recommen-dations in a Hospital Setting
HTA SYMPOSIUM

Please see below some of my peer-reviewed publications:

Peer-reviewed publications while at MUHC TAU

Almeida ND, Mines L, Nicolau I, Sinclair A, Forero DF, Brophy JM, Mayo N, Dendukuri N. A Framework for Aiding the Translation of Scientific Evidence into Policy: The Experience of a Hospital-Based Technology Assessment Unit. Int J Technol Assess Health Care. 2019 Jan;35(3):204-211.

Almeida ND, Suarthana E, Dendukuri N, Brophy JM. Cardiac Resynchronization Therapy in Heart Failure: Do Evidence-Based Guidelines Follow the Evidence? Circ Cardiovasc Qual Outcomes. 2017 Dec;10(12).

Semret M, Schiller I, Jardin BA, Frenette C, Loo VG, Papenburg J, McNeil SA, Dendukuri N. Multiplex Respiratory Virus Testing for Antimicrobial Stewardship: A Prospective Assessment of Antimicrobial Use and Clinical Outcomes Among Hospitalized Adults. J Infect Dis. 2017 Nov 15;216(8):936-944.

Dendukuri N, Chiu K, Brophy JM. Validity of electron beam computed tomography for coronary artery disease: A systematic review and meta-analysis. BMC Med. 2007 Nov 25;5:35.

Dendukuri N, Khetani K, McIsaac M, Brophy J. Testing for HER2-positive breast cancer: a systematic review and cost-effectiveness analysis. CMAJ. 2007 May 8;176(10):1429-34.

Dendukuri N, Brophy J. Inappropriate use of meta-analysis to estimate efficacy of probiotics. Am J Gastroenterol. 2007 Jan;102(1):201

Ligthart S, Vlemmix F, Dendukuri N, Brophy JM. The cost-effectiveness of drug-eluting stents: a systematic review. CMAJ. 2007 Jan 16;176(2):199-205.

Dendukuri N, Costa V, McGregor M, Brophy JM. Probiotic therapy for the prevention and treatment of Clostridium difficile-associated diarrhea: a systematic review. CMAJ. 2005 Jul 19;173(2):167-70. Review. Erratum in: CMAJ. 2005 Aug 16;173(4):345.

Oughton MT, Loo VG, Dendukuri N, Fenn S, Libman MD. Hand hygiene with soap and water is superior to alcohol rub and antiseptic wipes for removal of Clostridium difficile. Infect Control Hosp Epidemiol. 2009 Oct;30(10):939-44.

Bayesian Diagnostic Meta-analysis

Steingart KR, Schiller I, Horne DJ, Pai M, Boehme CC, Dendukuri N. Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults. Cochrane Database Syst Rev. 2014 Jan 21;(1):CD009593. doi: 10.1002/14651858.CD009593.pub3. Review. Update in: Cochrane Database Syst Rev. 2019 Jun 07;6:CD009593.

Merckx J, Wali R, Schiller I, Caya C, Gore GC, Chartrand C, Dendukuri N, Papenburg J. Diagnostic Accuracy of Novel and Traditional Rapid Tests for Influenza Infection Compared With Reverse Transcriptase Polymerase Chain Reaction: A Systematic Review and Meta-analysis. Ann Intern Med. 2017 Sep 19;167(6):394-409.

de Groot JA, Dendukuri N, Janssen KJ, Reitsma JB, Brophy J, Joseph L, Bossuyt M, Moons KG. Adjusting for partial verification or workup bias in meta-analyses of diagnostic accuracy studies. Am J Epidemiol. 2012 Apr 15;175(8):847-53.

Bayesian meta-analysis

Sinclair A, Xie X, Saab L, Dendukuri N. Lactobacillus probiotics in the prevention of diarrhea associated with Clostridium difficile: a systematic review and Bayesian hierarchical meta-analysis. CMAJ Open. 2016 Nov 24;4(4):E706-E718.

Latent class meta-analysis

Sinclair A, Xie X, Teltscher M, Dendukuri N. Systematic review and meta-analysis of a urine-based pneumococcal antigen test for diagnosis of community-acquired pneumonia caused by Streptococcus pneumoniae. J Clin Microbiol. 2013 Jul;51(7):2303-10.

Kohli M, Schiller I, Dendukuri N, Dheda K, Denkinger CM, Schumacher SG, Steingart KR. Xpert(®) MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance. Cochrane Database Syst Rev. 2018 Aug 27;8:CD012768.

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